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Limitations: Heart disease is multifactorial

In contrast, the overexpression of PCG-1 has shown protective effects against ethanol-induced neuronal death and toxicity [41]

Ryan-Harshman 2004)

The function of HO-1 in inflammatory reaction In various experimental models of inflammation, HO-1 induction produces favorable effects

The continuous stimulation of the hypothalamic receptors by cytokines, in systemic and chronic inflammatory diseases, can lead to the suppression of these receptors, with a consequent reduction in the response of the adrenergic neuroendocrine axes and, above all, the hypothalamic-pituitary-adrenal axis