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Studies have shown that the activation of T cells through the T cell receptor (TCR) can be affected by mechanical force, as antigens linked to a stiff surface can impair TCR-mediated activation (112114)

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The hydrogel displayed biodegradable properties with a porous microstructure, mean pores size between 25 to 115 m, and a high swelling ratio between 140.2 and 589% (Figure 4)

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TXG protects the colon by reducing the total inflammatory index, infiltration of inflammatory cells, submucosal edema, goblet cell loss, epithelial erosion, granulation tissue, epithelial hyperplasia, and crypt irregularity, abscesses and loss (124, 125)