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Postmenopausal osteoporosis (OVX) rat model: After 12 weeks of AOD 9604 treatment, the number of osteoclasts decreased by 35%, CTX levels decreased by 40%, and bone resorption rate decreased by 50%

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Rotate your injection spot every week (abdomen, thigh, or upper arm) to help prevent skin thickening or lumps

B12 inclusion theoretically mitigates this, but it cannot completely compensate for a 500-1000 calorie daily deficit

Because AOD-9604 and the incretins act through non-overlapping mechanisms (adipose lipolysis versus incretin signaling), some research protocols examine growth-hormone-fragment and incretin approaches in combination or in parallel arms which is why AOD-9604 appears as a "frequently paired" compound alongside semaglutide and tirzepatide