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A prediction of the intramolecular handover model is that the YY mutations in the GD would impair AAGABs binding to not only 2 but also , due to the role of the YY motif in mediating the attachment of the :2 hemicomplex to the GD of AAGAB

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Abstract Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which undergo biotransformation after administration to generate the API in situ

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