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541,542 Alterations in T-cell behavior result in heightened proinflammatory TH1 and TH17 responses, reduced immune monitoring affecting the elimination of infected or cancerous cells, diminished self-tolerance contributing to autoimmune conditions, and weakened natural defenses, ultimately fostering widespread inflammation

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The route of estrogen replacement is an important influence on GH requirement and those on oral estrogen are clearly more GH resistant than women using transdermal preparations (373,374)

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