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Some of these biological drivers that accelerate cellular aging include: Mitochondrial dysfunction (your cells ability to produce energy efficiently) DNA damage (which accumulates over time and affects cell function) Cellular senescence ( old or damaged cells that stop dividing but dont die off) Oxidative stress (an imbalance between free radicals and your antioxidant defenses) Chronic inflammation (low-grade inflammation that disrupts repair and immunity) Impaired tissue repair (a reduced ability to regenerate and heal) Hormonal changes (declines in key hormones that regulate metabolism, cognition, and more) Immune system decline (reduced ability to defend against threats and remove cellular waste) These internal biological mechanisms form a feedback loop that accelerates aging from the inside out

Functional analyses demonstrated that EV-mediated intercellular transfer of VDAC1 promoted PTX resistance in both in vivo and in vitro models

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10.1016/j.jhep.2024.11.007 14

Conclusion Cornelian cherry exhibits renoprotective effects against diabetic nephropathy in rats, primarily through attenuation of oxidative stress and enhancement of renal antioxidant defense