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The attenuated levels of these metabolites suggest that glucose supplementation (RPG or RUG) reprograms microbial tryptophan utilization patterns, potentially influencing feeding behavior and energy partitioning through gut-brain axis modulation [75]

proposed that glycolytic capacity, fatty acid oxidation, and mitochondrial respiratory activity are all impaired in the citrindeficient cells, whilst proteins and genes involved in lipogenesis, cholesterol, and bile acid metabolism are upregulated

The microglial responses are designed to engulf cell debris, mediate repair, and reduce the neurotoxic effects of localized necrosis and infiltrating blood components, but may not fully resolve injury, which may promote a perpetuating cycle of microglial activation and BBB injury

Maizels RM, Bundy DA, Selkirk ME, Smith DF, Anderson RM

A similarly large differential in toxicity between adult worms and mammalian cells for PAT was also found (Figure 6C)