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In plasma, longer chain FFA are combined with albumin , and in the cell they are attached to a fatty acid binding protein , so that in fact they are never really free. Shorter chain fatty acids are more water-soluble and exist as the unionized acid or as a fatty acid anion

Am J Hypertens 34:7381

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Additionally, the potential of itraconazole for treating various types of cancer has been explored in both preclinical experiments and clinical trials (NCT02749513)