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Genes such as calpain 2 ( CAPN2 ), collagen type I alpha 1 chain ( COL1A1 ), collagen type I alpha 2 chain ( COL1A2 ), collagen type VI alpha 1 chain ( COL6A1 ), collagen type VI alpha 2 chain ( COL6A2 ), and collagen type VI alpha 3 chain ( COL6A3 ) were identified as key genes [41]

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So far, most studies on KG and KGDDs have focused on the handful of DNA and histone demethylases