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Through both distinct and overlapping roles, IL-4 and IL-13 signaling through the IL-4 receptor alpha has shown to affect epidermal barrier dysfunction, increased susceptibility to skin infection, and chronic itch, factors that contribute to the development of eczematous skin lesions

reduced systemic target reach

Further studies are required to overcome these barriers and facilitate successful clinical translation of novel epigenetic approaches

Maria Guadalupe Cardenas, MD, is Board Certified in Internal Medicine and has more than 40 years of experience as an internist

Anisimov VN, Khavinson VKH, Provinciali M, Alimova IN, Baturin DA, Popovich IG, et al