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Additionally, the potential threat of high concentrations of GA (25100 M or 100 mg/kg/day) to male reproductive health, particularly its impact on male fertility, deserved special attention ( in vivo studies were needed to determine whether GA posed reproductive toxicity risks for females

[71] also reported that the activation of STAT3 enhanced the FoxO-dependent expression of inhibitor of B (IB) proteins which induced the accumulation of NF-B complexes into cytoplasm, inhibiting the pro-inflammatory NF-B-dependent gene expression

The apoptosis-inducing effects of supplementation with high doses of Se on leukocytes have been demonstrated in previous studies, which can be mediated by nuclear factor kappa B (NF-kB) inhibition [36]

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Lourenco et al., 2020)