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Also, mitochondrial dysfunction such as morphological alterations, electrolyte imbalance, and reactive oxygen species (ROS) generation has been considered an important element in PIPN

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Nat Med 16:897902 Fazio F, Zappulla C, Notartomaso S, Busceti C, Bessede A, Scarselli P, Vacca C, Gargaro M, Volpi C, Allegrucci M, Lionetto L, Simmaco M, Belladonna ML, Nicoletti F, Fallarino F (2014) Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice