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Some genetic diseases that involve defects of transcobalamin, methylmalonyl CoA mutase, or enzymes in the pathway of cobalamin adenosylation, may also result in vitamin B12 deficiency (IOM, 2000)

J Exp Biol 223(Pt 4):jeb196352

73,74 Moreover, tocilizumab has been shown to be effective against cytokine release syndrome resulting from CAR-T cell infusion against B cell acute lymphoblastic leukemia

Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes

Additionally, AS1411 is a candidate drug that targets nucleolin, which has been confirmed to be effective for treating renal cell carcinoma, 183 glioma, 184 and acute myeloid leukemia