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Peroxisome Proliferator-Activated Receptor Alpha Induction of Uncoupling Protein 2 Protects against Acetaminophen-Induced Liver Toxicity

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Human monocyte-derived dendritic cells express TrkB, and BDNF modulates their maturation, implying that BDNF/TrkB can alter antigen-presenting cell function and subsequent T-cell priming ( Careful anatomical and temporal annotation of receptor signaling, together with explicit consideration of murinehuman differences in NGF/BDNF expression, Trk isoforms, ligand affinity and immune-cell repertoires, is required to relate cell-intrinsic effects to stromal and immune phenotypes and to gauge the translational limits of murine OS models

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T.van der SchaftJ.van Os-MedendorpH.et al (2019)