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All authors contributed to the interpretation of the study and to further drafts

SAMe application alleviated these injuries in rats that underwent BDL ( Mat1a in mice resulted in depleted liver SAMe levels and reduced GSH levels, hypermethioninemia, marked changes in the expression of many enzymes of Met metabolism, and increased expression of many acute-phase markers and growth-related genes ( Mat1a - / - mice more susceptible to liver injury (60)

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cholestasis is generally mild and intermittent, with pruritus, normal GT, elevated BAs, and transaminases, but liver fibrosis is often present [42, 50, 51]

Therefore, older individuals might require more frequent B12 injections to maintain optimal levels compared to younger counterparts