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Epidemiological studies consistently demonstrate that elevated circulating BCAA levels are closely associated with increased risk of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) (38)

However, studies such as double-blind clinical trials with larger samples are needed to further demonstrate the efficacy of vitamin D analogs in combination with other traditional therapies in patients with alopecia areata

Whilst systemic corticosteroids and conventional immunomodulators have been the primary therapeutic agents, evolving strategies, including biologics and small molecules targeting tumour necrosis factor, different cytokines, or Janus kinase signalling pathways, signify a shift towards a precision management paradigm that considers individual clinical presentations

Therefore, reducing levels of inflammatory cytokines is an effective strategy for treating PF

Targeting the complement pathway in kidney transplantation