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Pregnancy and breastfeeding are also contraindications due to insufficient safety data

The lack of adequate cobalamin in the body hinders the regeneration of tetrahydrofolate, which eventually leads to megaloblastic anemia due to the functional folate deficiency.[9][10] On the other hand, the methylmalonyl-CoA mutase helps to metabolize odd chain fatty acids and branch chain amino acids.[5] Cobalamin is also thought to keep the bodys level of sulfhydryl (SH) groups in reduced form

Jacobsen, L

As a result, considerable attention is being devoted to both the type of antigens included in a vaccine, as well as the sequence of antigenic targets

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