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doi:10.3945/jn.114.201293 de Paz-Lugo P, Lupiez JA, Melndez-Hevia E

The recommended daily intake for adults is 1.5 micrograms, but higher supplemental doses ensure adequate absorption

Paradoxically, endogenous SAM accumulation or exogenous SAM treatment inhibits CRC proliferation, induces apoptosis (178, 179), and reverses promoter hypomethylation of oncogenes such as c-Myc and Ras (180)

JAMA Pediatr [Internet]

Natural compounds should be given more thought, since they can have extended therapeutic time windows, good pharmacological targets, and little side effects