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which is particularly concerning in thalassemia patients who already face increased thrombotic risk due to abnormal RBC membranes, platelet activation, and splenectomy [20-22]

The observation that PARP inhibition partly rescues vitamin C-treated cells may suggest that the toxic effect of DHA uptake is not caused by ROS alone, since restoring NAD + levels and glycolysis with the PARP inhibitor may actually decrease PPP flux and NADPH production, and aggravate the redox stress

The lead author is Carla Nasca, PhD, a postdoctoral scholar in McEwen's lab

For those with a personal or family history of diabetes, high blood pressure, blood vessel disease, or high blood sugar, semaglutide treatment should always be monitored by a qualified medical professional

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