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Description

Germline PHOX2B mutation in hereditary neuroblastoma

Dec 28 2016;8(36):1629-1636

Phase 1 clinical studies included 10 cohorts: 6 single ascending dose (SAD) cohorts (0.2, 0.6, 1.0, 2.0, 4.0, and 8.0 mg/kg) and 4 multiple ascending dose (MAD) cohorts (0.4, 1.0, 2.0, and 4.0 mg/kg)