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[PubMed Citation] Diaquacobinamide (H(2)O)(2)Cbi(2+) or its conjugate base hydroxyaquacobinamide (OH(H(2)O)Cbi(+))) can bind up to two cyanide ions, making dicyanocobinamide

The first evidence of an anticancer activity attributed to an NAPRT inhibitor was reported by our group in 2017 when we demonstrated that the prototypical NAPRT inhibitor 2-HNA cooperates with FK866 in blunting NAD + levels in the NAPRT-proficient ovarian cancer OVCAR-5 cells