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Golonka et al

15 Modulators of lipid composition Similar to ACSL4 inhibitors, deuterated PUFAs and MUFAs can also inhibit ACSL4 by decreasing PL-PUFAs

In animal studies, administering laurel and myrtle EOs to rats resulted in weight loss and improvements in lipid profiles (cholesterol, triglycerides, LDL-C, and VLDL-C) and atherosclerotic markers by regulating liver lipid metabolism (Odeh et al., 2022)

183,184 This regulation involves competition with FXR, which occupies DR1 sites and recruits corepressors under nutrient-rich conditions to suppress autophagy