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Description

H., Zhang, H

These data are in line with the previous study reported in vitro for macrophages and human smooth muscle cells, in which -tocopherol inhibits uptake of oxLDL by downregulating CD36 expression (Devaraj et al., 2001)

NaBPC157 markedly attenuated the lesions in rats in both pre-treatment and post-treatment conditions

The mechanism of treatment employs using the intrinsic cellular energy to reduce the active agent lipoate-[S-S] (actually a pro-drug) to dihydrolipoate [DHLA-(SH) 2 ] (the reduced active agent)