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Supportively, C1809 and C1813 locating in the kinase domain of mTRPM7, which are essential not only for the Mg 2+ sensitivity but also for kinase activity (Runnels et al., 2001), were shown to exert as the oxidative stress sensor in the presence of intracellular Mg 2+ (H

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1, 2, and 3 in the original) Evidence-Base Disclosure The published evidence base for Epithalon consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments