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Therefore, restoring TFAM levels by increasing mitochondrial biogenesis and reducing ROS production could protect cardiomyocytes from the oxidative damage of mtDNA induced by I/R-injury (93)

Moreover, a catechin compound isolated from the ethanol extract of Distylium racemosum branches, with IC 50 value of 30.2 g/mL, showed higher tyrosinase inhibition activity than arbutin as a positive control 271

doi:10.1172/JCI108627

This questions the view of saturation of the cell with H 2 O 2 to induce signaling pathways without regarding the compartment of ROS production [36,37]