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Like erythropoietin, most of the growth factors isolated have been glycoproteins, are very active in vivo, and in vitro interact with their target cells via specific cell surface receptors, and ultimately (via intracellular signals) affect gene expression, thereby promoting differentiation

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[Abstract] Res Sq

[PMC free article: PMC3431581] [PubMed: 22962670] 663

In contrast, the Ribas laboratory revealed that in melanoma patients who respond well to anti-PD-1 treatment, the proliferation of intratumoral CD8 + T cells is directly correlated with a reduction in tumor size [32]