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Since VgluT2 is expressed in synaptic vesicles of presynaptic membranes 26 , these findings suggest that the MOR + fibers in the DMV are derived from upstream excitatory neuronal projections, likely conveying signals from other brain regions to promote opioid-induced constipation

Although it lacks regulatory approval for human or veterinary administration, BPC 157 remains an object of significant interest within academic and experimental research frameworks