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A systems-based approach and customized drug testing techniques may be required to gain a deeper understanding of the underlying mechanisms and causes ( Integration of pharmacogenomics, metabolomics and microbiomics: Path to personalized metformin therapy Until recently, personalized medicine in T2D has predominantly focused on variation in DNA sequence

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Additionally, oxidative stress has also been found to activate RIP1/RIP3/MLKL signaling pathway and enhance the formation of necrosome (51)

In the next sections, we review what we have learnt about the effects of UV light on lens transparency from a variety of different animal models and critically assess whether these models accurately model the effects of UV exposure seen in the human lens

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