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[0382] In some embodiments, after treatment with a therapeutically effective amount of a composition of the disclosure, the number of brown spots decreases by about 1 %, about 5 %, about 10 %, about 15 %, about 20 %, about 25 %, about 30 %, about 35 %, about 40 %, about 45 %, about 50 %, about 55 %, about 60 %, about 65 %, about 70 %, about 75 %, about 80 %, about 85 %, about 90 %, about 95 %, or more

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Acknowledgements This work was supported by grants from the National Key Research and Development Program of China (2021YFA0909900), National Natural Science Foundation of China (52233013), Key Project of Science and Technology Commission of Zhejiang Province (2024C03083, 2024C03085 and 2024C03168), Zhejiang Universitys start-up packages, Fundamental Research Funds for the Central Universities (2021FZZX001-46), the Starry Night Science Fund at the Shanghai Institute for Advanced Study of Zhejiang University (SN-ZJU-SIAS-009) and Juvenile Diabetes Research Foundation (grant number 2-SRA-2021-1064-M-B)