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Ibrahim RB, Yeh SY, Lin KP, Ricardo F, Yu TY, Chan CC, Tsai JW, Liu YT

Despite this complexity, numerous studies have reached conclusions on the intricate process of ASM remodeling, which includes ASM cell proliferation and apoptosis (255, 256), dysregulation Ca2+ homeostasis (257259), excessive production of ECM components like fibronectin and collagen type I that play a role in stimulating the proliferation of human ASM cells (260264), and factors associated with immune cells, airway cells, growth factors, cytokine and inflammatory mediators (263, 265268)

Zhang et al., 2018)

The relative balance between Treg cells and effector T helper cell subsets appears to be more relevant than the absolute number of Treg cells

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