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Date of Acceptance: December 13, 2019 Abbreviations: reactive oxygen species, ROS

Another unresolved question is whether other metabolic pathways, in addition to mitochondrial respiration, participate in cuproptosis

Physicians Edinb

Earlier studies demonstrated that IGF-1 depletion could restore antigen presentation and CD8 T-cell infiltration in preclinical glioma models, suggesting that IGF-1 may impair anti-tumor immunity by disrupting antigen processing and enhancing immunosuppressive signaling