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The outcomes of advanced AKI (KDIGO stage 2, 3) and all-cause in-patient mortality, as composite outcome, were recorded

Durvalumab or pembrolizumab combined with CisGem is already approved by the FDA and EMA in this indication and both are recommended by most national and international guidelines as first-line treatment in biliary tract cancer, especially taking into account that the 24-month survival rates in both studies are comparable (23.6% 308 versus 25% 310 , respectively)

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When treating the vessels, the pulsed dye laser decreases the stimulus to melanocytes and subsequently the recurrence of the spots

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