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Brain-targeted delivery of protein using chitosan- and RVG peptide-conjugated, pluronic-based nano-carrier

Fogoros, R

Riedl, JM, Fece de la Cruz, F, Lin, JJ, Parseghian, C, Kim, JE, Matsubara, H, Barnes, H, Caughey, BA, Norden, BL, Morales-Giron, AA, Kushner, EW, Ehnstrom, S, Nakamura, H, Patel, PS, Ellis, H, Pappas, L, Vakaris, A, Gainor, J, Kopetz, S , Klempner, SJ, Parikh, AR, Hata, AN, Heist, RS, Corcoran, RB

However, HPV E7 promotes TRIM21-mediated degradation of IFI16, thereby preventing inflammasome assembly and pyroptotic cell death

One can also use for elution a mobile phase with an increased pH (e.g., pH 10), which creates a net charge that destabilizes hydrophobic interactions