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doi: 10.3389/fendo.2026.1800681 Received 31 January 2026 Revised 02 March 2026 Accepted 04 March 2026 Published 20 March 2026 Volume 17 - 2026 Edited by Martine Culty, University of Southern California, United States Reviewed by Jiangang Hou, Fudan University, China Leyla Aydn, Yildirim Beyazit University Yenimahalle Training and Research Hospital, Trkiye Updates Copyright 2026 Qin, Wu, Mo, Shen, Tan, Li, He and Peng

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Before enrollment, all involved patients provided written informed consent to participate in the study and have their data and pictures anonymously used for publication

Identification of ferroptosis genes in MYCN -amplified cells To systematically identify the cellular vulnerabilities associated with high MYCN expression, we performed an unbiased synthetic lethal small interfering (siRNA) screen using high/low MYCN IMR5/75 cells (Fig