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The clinical titration starts at 0.25 mg weekly and increases every four weeks up to a maintenance dose of 2.4 mg weekly, though some research protocols extend up to 4.5 mg

Sandoval TA, Salvagno C, Chae CS, Awasthi D, Giovanelli P, Marin Falco M, Hwang SM, Teran-Cabanillas E, Suominen L, Yamazaki T, Kuo HH, Moyer JE, Martin ML, Manohar J, Kim K, Sierra MA, Ramos Y, Tan C, Emmanuelli A, Song M, Morales DK, Zamarin D, Frey MK, Cantillo E, Chapman-Davis E, Holcomb K, Mason CE, Galluzzi L, Ni Zhou Z, Vhrautio A, Cloonan SM, Cubillos-Ruiz JR