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Initiation of the chain reaction of lipid peroxidation requires the spark provided by the reduction of Fe +3 to Fe +2 using a single electron provided by the O 2 - (superoxide anion radical) formed during oxidative respiration in mitochondria

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reported two proline substitutions (2P) at the apex of the central helix and HR1 that can retain the S proteins of MERS-CoV, SARS-CoV and HKU1 in the antigenically optimal pre-fusion conformation 85 (Fig