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Magnetically guided capsule endoscopy and magnetic resonance enterography in children with crohns disease: manifestations and the value of assessing disease activity

Surprisingly, not only CD44 variant isoforms, but also CD44s have been identified as CSC markers in prostate, colon, gastric, pancreatic, ovarian and breast cancers (Kimura et al., 2013

& Southwick, F

Int J Mol Sci (2014) 15(3):364059

While native IGF-1 within physiological ranges appears safe, supraphysiological stimulation of IGF-1 receptor signaling through exogenous administration of potent analogs like IGF-1 DES could theoretically promote growth of existing pre-malignant or malignant cells, accelerate tumor progression, or support metastatic spread by enhancing cell survival and proliferation while inhibiting apoptosis