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1 Introduction Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, with an incidence of approximately 35 cases per 100, 000 people, accounting for approximately 49% of all malignant brain tumors, and is associated with extremely high recurrence and mortality rates ( Compared with normal brain tissue, GBM cells exhibit significant metabolic alterations (e.g., the Warburg effect) and changes in key metabolic pathways, including fatty acid synthesis, glutamine metabolism, and the tricarboxylic acid (TCA) cycle ( Ferroptosis is a cell death mechanism that is dependent on the accumulation of iron ions and lipid peroxidation and is distinct from apoptosis, necrosis, and autophagy

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To consider the dose- and time-dependency of the model, we also tested a low dose of 10 ng h 1 for 9 days (low dose, longer time), 100 ng h 1 for 3 days (high dose, shorter time) and an acute treatment for 24 h (3 1.5 g, every 8 h)

Its increase usually paralleled the inflammation severity 58,59

Veg-Table Dietary Nitrate Scoring Method What is the optimal timing and dose of nitrate-containing vegetables, such as beets and spinach,