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Additional doses can be administered relatively rapidly to alleviate residual symptoms, typically 8 mg Q1-2hr PRN up to a maximal cumulative dose of ~32 mg if needed

Code availability All scripts used for simulations in this research are publicly available (GitHub diederiklt/YeastHighTemperatures)

Lyophilization helps support long-term stability during storage and transportation when handled under recommended laboratory conditions

Figure 3 Having demonstrated that metformin treatment alone induces cell death in both HCT116 and SW837 cells, the impact of metformin combined with a clinically-relevant dose of 1.8 Gy radiation was assessed at 48 h post radiation exposure