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Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear

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FIGURE 5 Concluding Remarks Radiation exposure to key endocrine organs (e.g., hypothalamus, pituitary, thyroid, and gonads) places cancer survivors at the highest risk of developing an endocrine abnormality over time, these endocrinopathies can develop decades following cancer treatment (Sklar et al., 2018), and are also observed in survivors treated with radiation to the head, neck, or pelvis ( in vivo and in vitro experiments is necessary

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Although these studies primarily focus on safety and tolerability, they also provide the first human data on pharmacokinetics and, early pharmacodynamic (biomarker)effects