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As we stated in the CY 2024 OPPS/ASC final rule with comment period (88 FR 82079), while the MRF format is designed to be used by innovators, employers and researchers and to be ingested into machines for further processing of the data, the information contained in a MRF is critical for driving competition and directly beneficial for patients

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This substitution may potentially increase the resistance of the peptide to enzymatic degradation and improve its stability