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doi: 10.1159/000331751 30 LawrenceN.DennisA

In vitro and in vivo Down syndrome models revealed that supplementation of mice with low molecular weight antioxidants such as -tocopherol reduced the level of oxidative stress, attenuated degeneration of cholinergic neurons, and improved working memory (Lockrow et al

Some researchers eventually use up to 100mg daily for enhanced effects, though this should be approached gradually

*Correspondence: Peng Xiong, [email protected]

Levels of total glutathione (reduced plus oxidized), GSH, oxidized glutathione (GSSG) and GSH/GSSG ratios were mostly unchanged by IF, with a few exceptions: Livers of IF rats presented a significant increase in total glutathione and reduced GSH contents, which may be a consequence of a chronic exposure to a slightly increased oxidant generation (Fig