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Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015

For example, HSP90 inhibitors such as ganetespib not only disrupt chaperone function but also enhance autophagy, leading to the degradation of oncogenic proteins in cancer

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APOE, APOE promoter, and tau genotypes and risk for concussion in college athletes