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As we age, NAD+ levels decline significantly, contributing to fatigue, metabolic slowdowns, and cellular aging

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

Some medical conditions, including autoimmune disease like shingles (herpes zoster), rheumatoid arthritis or celiac disease, as well as Lyme disease, some cancers, and several other diseases can also cause or increase the risk of nerve damage, also sometimes referred to as peripheral neuropathy