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Furthermore, while ferroptosis induction has attracted major therapeutic interest, ferroptosis resistance should not be viewed as a passive absence of death signaling, but as an adaptive survival program selected during platinum exposure, PARP inhibition, hypoxia, and metastatic dissemination

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What sets this review apart is its focus on the translational dimension: highlighting recent advances in delivery systems to overcome bioavailability challenges and identifying gaps that must be addressed through clinical research

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and may guide intensification of treatment of COVID-19-associated uncontrolled inflammation (99, 183, 261, 262, 265, 267269)