In a fifth aspect, the invention relates to a pharmaceutical composition, hereinafter pharmaceutical composition of the invention, comprising fingolimod, an analogue, metabolite or derivative thereof or a pharmaceutically acceptable salt, and one or more drugs selected from the group consisting of an antioxidant, an antioxidant targeted to mitochondria, a histone deacetylase inhibitor, an inhibitor of mitochondria transition pore opening, an anti-inflammatory drug, a PPAR agonist, a RXR agonist, asirtuin1 agonist, an hypolipidemic drug and an autophagy activator
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Hoyos-Ceballos GP, Ruozi B, Ottonelli I, Da Ros F, Vandelli MA, Forni F, Daini E, Vilella A, Zoli M, Tosi G, Duskey JT, Lpez-Osorio BL