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Cytosolic calreticulin has the ability to bind to PS on the inner leaflet in a Ca 2+ -dependent manner in close proximity to the flipase, aminophospholipid translocase (APLT)

290 Trx is necessary for the nerve growth factor (NGF) signalling through its cAMP responsive element to drive expression of c-fos, which has been hypothesised to be critical for the function of NGF