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Sustained UPR can promote the development of MAFLD by regulating lipogenesis, causing inflammation, and inducing hepatocyte death (Lebeaupin et al., 2018

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There are several factors that lead to why one may have TMAU or may develop this rare disease

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Incomplete FAO leads to the accumulation of even-chain acylcarnitines from C4 to C22 in the mitochondria, with a corresponding decrease in carnitine levels [6]

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