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We further discuss emerging advances in omics, spatial biology, genome editing and artificial intelligence that enable deeper mapping and predictive modeling of proteostasis networks, paving the way toward personalized, mechanism-based interventions

Statements Author contributions XL drafted the manuscript by reviewing the literature

Phenotypic assessment of PZQ activity on NTS About 200 NTS incubated at 37 C in a 5% CO 2 incubator overnight were exposed to different concentrations of PZQ (1, 5, 10, 20, 30, 40 and 50 M) and control without treatment for 24 h in triplicate

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The potential mechanisms of action are summarized in Figure 3