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Melatonin, a widely recognized hormone responsible for regulating the sleepwake cycle, acts as a powerful natural antioxidant

4b) but cannot be used for enzymatic production (Supplementary Fig

In early Alzheimers disease (AD), excessive glycolysis leads to intracellular lactate accumulation, triggering excessive histone lactylation, amplifying glycolysis-related gene expression, and creating a feedback loop that exacerbates glucose metabolism in microglia [130]